Sentence examples for causes significant difficulties from inspiring English sources
This causes significant difficulties with the convergence of finite element solutions.
However, the asynchronous nature of an infection causes significant difficulties in determining host genes responsive to a single viral gene product.
This project has in recent years inadvertently caused significant difficulties in forming a stable, collaborative, national government, a stasis that grieved his generation.
Later the same year, Scotland's Chief Inspector of Constabulary warned the sheer scale of Ore was causing "significant" difficulties for forces.
The poor quality of communication between professionals, perhaps reflecting a limited understanding of the various roles in patient care, we found to cause significant difficulties.
In combination with other health issues (e.g. limited mobility and managing diabetes) this mild memory problem caused significant difficulties and concern.
In cheese factories, delays to fermentation can cause significant difficulties in a process that is based on a perishable starting material (milk) that cannot be stored in the event of delay.
In the Affymetrix systems the signal from one badly designed probe, which may be based on inaccurate data from a sequence database, can be easily eliminated from further analysis [ 41] without significant decrease in the precision of gene expression estimate, while in the Agilent systems the same design glitch might cause significant difficulties in the evaluation of gene expression levels.
However, Stausberg et al. demonstrated that the agreement in coding decreased when more detailed (for example five digit versus three digit ICD-10) codes were used and concluded that very detailed classification and complex coding rules for ICD-10 diagnoses cause significant difficulties even for coding experts [ 30].
