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Inflammation causes sensitization of peripheral and central nociceptive neurons.
It is possible that extracellular acidosis induced by acetazolamide causes sensitization of intracranial perivascular nociceptors, which, in combination with vasodilatation, leads to delayed headache in healthy volunteers.
It is possible that extracellular acidosis induced by acetazolamide causes sensitization of cephalic perivascular nociceptors, which, in combination with vasodilatation, leads to delayed headache.
application of SP causes sensitization to heat in a similar fashion to the capsaicin-mediated thermal hyperlagesia described above.
In other mammals, SP plays an important role in nociception: it is released from C-fibers onto spinal neurons where it facilitates NMDA receptor activity and causes sensitization that can last for minutes, hours or days.
It however remains to be determined what causes sensitization in the Hep3B and HuH6 cell lines.
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It is rare for a mother to become sensitized during the course of her first Rh-positive pregnancy because the amount of fetal Rh antigen that enters maternal circulation is insufficient to cause sensitization; usually only during labour will exposure be significant.
Critical levels of these substances are thought to cause sensitization and activation of trigeminal neurons in the afferent loop and, in turn, activate second-order neurons in the trigemino-cervical complex.
One reported hypothesis is that altered pain modulation due to nociceptive stimuli arising from pericranial myofascial tissues may cause sensitization in the trigeminal nucleus, thalamus, or somatosensory cortex [7].
Panel c shows peripheral sensitization after tissue injury, which results in the release of a number of inflammatory mediators (e.g., histamine, bradykinin, prostaglandins, interleukins, adenosine, and nerve growth factors) that, in turn, induce the expression of transient receptor potential (TRP) channels and cause sensitization of the peripheral nociceptor.
Agonists cause sensitization to the presence of the ligand or directly stimulate receptors, hence the temperature increase is produced by increased physical activity.
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