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The cause (or causes) of wasting disease, CLE, is not known though several pathological features have now been identified including inflammation of the small intestine and pancreas [ 27].
In an autopsy study done in the Ivory Coast to study the causes of wasting, 44% of wasted HIV positive patients who died had TB [ 13], indicating that weight loss suggests TB in HIV-infected Africans.
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However, it caused amelioration of wasting of the disease, as judged by a reduction in the other clinicopathological characteristics of DSS-induced colitis, compared with their respective controls (PBS or isotype antibody treatment) (figure 6A).
Although Google has filters to detect outright click fraud, unintentionally clicking on an ad region may be a less insidious yet hard to detect cause of wasted ad dollars.
Over the past decades, the under-reporting of trial results has been increasingly acknowledged as a major cause of wasted research.
For decades, misidentified and contaminated cell lines have been a high-profile cause of wasted research effort and funding, and false claims in the literature [ 1– 3].
Moreover, tissue-specific impairment of autophagy in central nervous system tissue causes massive loss of neurons, resulting in neurodegeneration, while impaired autophagy in liver tissue causes accumulation of wasted organelles, leading to hepatomegaly.
Distinguishing between the causes of waste and the location where it occurs is crucial.
Matt Prindiville is the associate director for UPSTREAM, a US-based environmental policy organization dedicated to addressing the root causes of waste.
But fewer fireworks and more somber parties will not get to the core causes of waste: the legions of Chinese officials who take bribes and siphon off government funds.
First, regulators should use their influence to reduce other causes of waste and inefficiency in research.
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