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The causes of transformation in DT40 were known to include an insertion of ALV into the c-myc gene.
In addition to ALV, we looked for additional causes of transformation among mutated genes and found the PIK3R1 and ATRX mutations.
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Restriction-modification (RM) systems are the most common cause of transformation recalcitrance in bacteria and potently inhibit plasmid transfer [ 17, 26].
We think that most gene transcripts that are over expressed in BG01V APCs relative to H9 APCs are consequences of premalignant transformation rather than causes of premalignant transformation.
RAR-β2 re-expression causes reversal of transformation, cell cycle arrest, and restoration of retinoid sensitivity.
My research involves the investigation of the causes, mechanism of transformation and altered growth control, and development of new methods of therapy for primary brain tumors and those metastasizing to the CNS and its protective coverings.
Hydrological modification, watershed urbanization and the changes in ecosystem use were identified as the main causes of wetland transformation with the causes and consequences of the transformation having complex feedback loops.
Loss of the p53 function is one of primary causes of cellular transformation.
Such analyses, coupled with whole transcriptome sequencing, can shed further light on the causes of oncogenic transformation.
There are multifarious potential causes of such transformations in one's affective responses to an object, and those causes can be immediate or unfold over time.
In contrast, the deactivation of the inhibitory transforming function of PTEN causes malignant transformation of endometrial cells [ 30].
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