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Second, high-density SNP genotyping across multiple populations are required for robust inference and localization of selective effects, and inferences regarding the causes of selection require functional-genomic or ecological-genomic data (Hughes 2007), such as localization of signals to particular functional domains.
The intensity and breadth of resource use that these mutations confer provides insight into the ultimate causes of selection.
5 In every study, some variables influence whether someone will take part in the study or not (ie, causes of selection status).
Similar(57)
A strong iHS signature near the end of chromosome 6 was also detected, as previously observed in other populations8,9,10,13,23, for which the cause of selection is unknown.
Thus, Matthen and Ariew (2002, 56) write, "Unlike vernacular [individual] fitness, predictive [trait] fitness is not a cause of selection, or of evolution for that matter….
This could be a potential cause of selection bias.
First, use of hospital-based control in this study for potential cause of selection bias.
The latter observation is critical; as it provides a putative functional link between the cause of selection and the evolutionary response exhibited in morphological change.
On-going directional selection causes footprints of selection identifiable as regions where the derived allele frequency is higher than non-selected regions [ 29, 85, 86].
Other limitations of this study are found in two causes of possible selection bias.
Additionally, the actual causes of disruptive selection have been relatively understudied.
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