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Furthermore, the causes of response variability as seen in the 10% nonresponders in the Symplicity HTN-2 trial have not yet been well elucidated, with queries of incomplete denervation or sympathetic reinnervation foremost in mind.
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In contradistinction, independent component analysis (ICA) is a data-driven method based on the assumption that the causes of responses are statistically independent.
Therefore, as the reviewers suggest, even if protonation is the direct cause of response, it still may need a conformational change (triggered by either binding or transport).
NT-pro-BNP (Brain Natriuretic Peptide) is a prehormone synthesized in myocytes released cause of response to stress and increased in hypovolemia, renal failure status and by age [ 5].
Our original intent in pursuing these studies was to investigate the causes of differential response to V-ATPase inhibitors seen in cancer cells.
Our finding of an increased average estrogenicity of serum extracts obtained from an exposed population merits attention and should inspire further studies into the causes of this response.
However, our in vitro observation that hypoxia significantly increases CXCL-1 secretion from lung epithelial cells strongly suggests that alveolar hypoxia is one of the main causes of inflammatory responses in atelectatic lungs.
The causes of autoimmune responses leading to human kidney pathology remain unknown.
Potential causes of non-response in the first phase, where specialist HCPs are asked to participate, may be at the institutional or specialist level, whilst causes of non-response in the second phase may be patient specific.
This new perspective on network-level causes of brain responses to dynamic stimuli opens several future research avenues.
There are no records of the initial causes of or responses to such altered genetic codes; further adaptations to and details of eventual fixation are completely unknown.
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