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What can we say about the causes of length difference between the two epigenetic groups with the data in hand?
Two linkage groups (5 and 3) were slightly smaller in map A, while the remainders were significantly longer, suggesting that the causes of length differences varied between chromosomes.
We have excluded G + C content, recombination, and repetitive sequences as main causes of length differences, although the importance of the latter two factors needs to be revisited with improved annotations of the honeybee genome.
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Nevertheless, our analyses indicate that we can rule out simple and interspersed repeats as the main cause of length difference between low- and high-CpG genes in A. mellifera.
The sample population was further sub-classified into those with congenital or acquired causes of limb length discrepancy.
Both monosegmental and bifocal lengthenings were undertaken for acquired and congenital causes of limb length discrepancy in a large number of cases.
"The reasons for some animals being long-lived and others short-lived, and, in a word, causes of the length and brevity of life call for investigation," wrote Aristotle in 350 B.C.E.
Appendix 6. Causes of Variation, Length of Stay.
Since stride length determines many other locomotor parameters, including speed and energy costs (Gray, 1944; Jones and Lindstedt, 1993; Pontzer, 2007a), understanding the underlying causes of stride length variation is a key to determining how and why animals walk the way they do.
Causes of leg-length discrepancy were found to be diverse with 16 cases from congenital causes including developmental dysplasia of the hip, congenital short femur and proximal focal femoral deficiency.
Data on the extent of the disease, pathomorphology of the tumor, treatment method, extent of breast and axillary lymph node surgery, complications after the surgery, disease recurrence, cause of death, length of survival, and length of breast cancer-specific survival were collected.
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