Similarly, studies looking at dendritic degeneration following NMDA insult demonstrate that microtubule stabilization is upstream of calpain activation and loss of MAP2, suggesting that loss of MAP2 is not the cause of microtubule destabilization in this instance [ 49].
Even a conservative mutation of Lys27 to Arginine causes ∼1000-fold ∼1000-foldation of the toxin-channel complex in Shaker (Goldestabilization1994).
Using our gain-of-function approach, we show that an increase in miR-308 causes a destabilization of dMyc mRNA and reduced dMyc protein levels.
The effect of removing cysteines 6 and 111 on the yield of amyloid, even in the absence of ALS mutations, is difficult to explain; the replacement of these two cysteines may either cause some destabilization of the tertiary structure of SOD1 [42] or promote the formation of amyloid instead of other types of aggregates, like amorphous aggregates.
Trifluoperazine (TFP, 20 μM), a blocker of calmodulin caused destabilization of the AC as early as 15 min after application.
In fact, NF-kB allows the expression of transcripts needed for cell cycle progression and causes destabilization of MyoD mRNA and degradation of MyoD protein, negatively affecting the capacity of muscle to terminal differentiation [ 5].
Prediction of SNPs that cause a destabilization of the protein structure was made using CUPSAT (Parthiban et al. 2006).
Taken together, these results suggest that disruption of Pri2's Fe-S domain causes destabilization of the Pri2 protein, which impairs the initial step of DNA synthesis resulting in cell cycle arrest in S phase with a G1 DNA content.
Binding of 1α,25-dihydroxyvitamin D3 to the full-length VDR causes destabilization of the VDR homodimer and formation of a heterodimeric complex with the 9-cis retinoic acid receptor (RXR).
Hence, a decrease in the levels of these polycations might cause a destabilization of important cell structures, leading to alterations in cell integrity and inducing cell death.
