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These findings add an important and previously overlooked component to the causes of dengue vascular leak, identify a new potential target for dengue therapeutics, and support inclusion of NS1 in dengue vaccines.
Dengue is a multifactorial disease, and although there is much information on the presence of the disease, there is limited information on the causes of dengue mortality.
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The immune misfiring and resulting cell suicide, Mongkolsapaya says, could be a primary cause of dengue hemorrhagic fever.
The knowledge displayed was profound not only regarding the cause of dengue but also vector control.
DENV are the cause of dengue fever and the more complicated forms of diseases, dengue haemorrhagic fever and dengue shock syndrome.
Dengue virus, transmitted by mosquitoes, causes every year 50 million cases of dengue fever.
The four dengue virus serotypes (DENV1 to DENV4) are mosquito-borne flaviviruses that cause up to ~100 million cases of dengue annually worldwide.
There were no cases of dengue detected (neither dengue caused by vaccine nor wild-type virus) in either vaccine group.
Estimated annual incidence of disease caused by dengue virus (DENV) is 50 100 million cases of dengue fever and 250,000 cases of dengue hemorrhagic fever; mortality rate is 25,000 per year in tropical and subtropical countries.
An outbreak of chikungunya virus infections that occurred in Italy during the summer of 2007 involved >200 persons (1 ). A. albopictus mosquito spread in Hawaii was regarded as the cause of a dengue outbreak in 2001 (9 ), and in Florida, dengue fever was recently documented in Key West, where A. aegypti mosquitoes are established (10 ).
DENV-3 was confirmed to be the cause of the dengue outbreak described herein.
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CEO of Professional Science Editing for Scientists @ prosciediting.com