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The hypoxia-induced synthesis of HIF-1 α causes modification of tumor microenvironment.
Model composition sometimes causes modification of some properties of the initial models, resulting in new testable predictions.
Rules marked as crucial receive special attention, not only during construction of the computational model but also later, during software development when infeasibility causes modification of the problem and removal of required rules (requirements).
Under these conditions there is an increased sympathetic adrenergic tone and reduced parasympathetic activity [ 3], a combination that causes augmented ventricular workload and oxygen demand, increasing the occurrence of ischemic events, and causes modification of the ionic currents across the cellular membrane, leading to direct electrical instability of myocytes.
Fluorescent biomarkers have been employed in cell sorting and characterization, but fluorescent techniques have a number of drawbacks, that is, photobleaching prohibits long-term studies, production of free radical singlet oxygen species will damage live cells, finally, the use of biomarkers causes modification to cells' surface chemistry.
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This causes modifications in the well-known composting evolution pattern.
To determine whether hypercholesterolaemia treatment with pravastatin causes modifications in plasma fibrinogen.
Space weathering is a fundamental process on airless bodies that causes modifications of mineral surfaces via (i) irradiation by cosmic rays and, in particular, by solar wind ions and/or (ii) via impacts of micrometeorites.
CPP causes modifications in several dimensions of patients' personal life.
High temperature causes modifications in membrane functions, associated with alteration of membrane fluidity.
Moreover, β-elimination causes modifications not only of phosphorylated serine and threonine but also of their O-glycosylated forms (Rusnak et al. 2004).
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