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The possibility of different underlying causes for monoallelic expression emphasizes the importance of conducting reciprocal crosses to detect genuine parent-of-origin-specific expression patterns, a practice that has been absent from many past studies of marsupial imprinted genes.
Currently, the causes for gene expression variances among RA patients are unknown.
Therefore, pulse pile-up could be ruled out as the leading cause for the expression level-dependent fluorescence lifetime variation.
However, whether the nucleosome reorganization was the leading or a minor cause for gene expression divergence is subject to debate (Tirosh et al. 2010; Lin and Li 2011a).
Recent evidence suggests that alteration in chromatin structure at the FMR1 locus rather than increased RNA stability is the main cause for enhanced expression of the premutated gene.
One possible explanation for the absence of E-IAA in the A36.4 PLN sample is that the selected sub-phenotype marks the disease stage without being per se the cause for the expression patterns identified.
This data suggested that demethylation restored the expression of miR-874 in HNSCC and fibroblast cells and that reduction of the HDAC1 expression was caused by recovery for expression of miR-874 in cancer cells.
Possible causes for the spontaneous expression of fragile sites and their potential biological significance are discussed.
Expression analysis of PpSPL1 and PpNAC indicated that these genes could be one of the factors for regulating PpMYB10.1 expression levels in 'Mochizuki' and 'Akatuski', but other factors would be also involved in the cause for differential expressions observed (Fig. 3b).
Addressing the potential causes for CYP19 over-expression, we analysed the gene copy number for CYP19 using qPCR.
By utilizing dPORE-miRNA to extract information about: a/the SNPs that reside in the regulatory regions of miRNAs and b/the potential effects that these SNPs may have on TF binding, the user can gain an insight into potential causes for changes in miRNA expression levels that might aid to explain the differential expression of known oncogenes in cancerous tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com