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There are several studies comparing expression profiles in testes between cryptorchid and normal males investigating the resulting effects of but not causes for development of CO (e.g.[ 75, 76]).
Loss of the putative tumor suppressor, Cav-1, is believed to be one of the causes for development of several types of cancers, but evidence also show that overexpression or re-expression of Cav-1 in advanced stages of the disease may contribute to tumor progression.
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Future studies on fetus development should address causes for abnormal development (i.e., reduction in size) and death of offspring.
However, smoking parameters like amount and duration of smoking may not be the correct measures in validating initiating causes for CRC development.
As mentioned above, obesity is a primary cause for development of insulin resistance, and insulin resistance always accompanies with metabolic disorder.
Lipid oxidation is the major cause for development of rancidity and off-flavor compounds in edible fatty products such as peroxides, ketones, aldehydes and oxyacids [1, 2].
Regarding the latter; seen from a causal perspective, exposure to training load is the only necessary cause for development of RRI, since no RRI is able to occur without engaging into running practice.
Neurotropic viruses (e.g., HIV) disturb the normal adult neurogenesis pattern, a possible cause for development of dementia in these patients.
The use of antimicrobials is the main cause for development of antimicrobial resistance.
A further challenge in personalizing treatment is the identification of the cause for development of resistance, which may impact upon treatment selection.
It is widely accepted that the absence or failure of immune tolerance to islet β cells is the primary cause for development of T1D.
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