In addition to genetic mutations, epigenetic modification is another common cause for altered gene expression, among which promoter methylation and histone modification are the most frequently observed.
This study provides empirical evidence that land cover type, which is strongly correlated to temperature, is the primary cause for altered flowering phenology of brittlebush in the Phoenix area, although water availability may also be important.
As detailed above there are many causes for potential altered PK in patients both with sepsis or trauma.
Large-scale wildfires are a pervasive threat to the global status of the Mallee Emu-wren, and the risk to remaining populations is exacerbated by the adverse impact of prolonged drought and the potential for altered fire regimes caused by global warming.
Our protein expression and cell assay data identified increased intracellular (oxidative) stress as a potential cause for the altered MSC function.
Second some patients who were not referred to a support agency may have been referred later following investigation by a GP for example, routine blood tests or infection screens to rule out an organic cause for the altered behaviour.
In addition, cisplatin adduct formation was comparable in bulk cells and TICs (cisplatin 40 μM, 6 h and 10 μM, 24 h), hence ruling out inefficient drug accumulation as the main cause for the altered cisplatin sensitivity (Supplementary Figure 1B).
By electing to study SNPs causing non-conservative substitutions, we expected to observe evidence for altered channel properties.
There is precedent for altered mitochondrial Ca2+ loading, morphology and function caused by changes in ER protein function.
As discussed here, there is substantial evidence for altered taste sensitivity, taste-guided liking and wanting, and neural reward processing in the obese, but it is not clear whether such traits cause obesity or whether obesity secondarily alters these functions.
