Recent work has shown that the devastating symptoms of this disorder are correlated with the elevated levels of NAA observed in these patients, caused as a consequence of the inability of mutated forms of aspartoacylase to adequately catalyze its breakdown.
ConA-induced hepatitis is a well-established model for hepatitis caused as a consequence of T and NKT cell activation [14], [37].
In preterm pregnancy pPROM can be as well a cause as a consequence of chorioamnionitis.
Recently, the splitting of the resonance modes has been observed, which is caused as a consequence of clockwise and anti clockwise propagating mode coupling.
The hyperglycemia is caused as a consequence of a deficiency in insulin in type 1 diabetes (T1D), and is a feature of late type 2 diabetes (T2D) along with insulin resistance.
Trypanosomiasis is responsible for many reproductive disorders in bovine herds such as the degeneration of the hypothalamus, the pituitary gland, and the gonads causing, as a consequence, alterations to the concentration of secretions and plasmatic concentrations of essential hormones for reproduction in both males and females [ 2, 10].
R88 is the equivalent of R112 in human XPD which when mutated to a histidine results in an inactive helicase and causes trichothiodystrophy as a consequence of defective NER (Dubaele et al, 2003; Nishiwaki et al, 2004, 2008).
Moreover, both loss and gain of Notch function cause hyperkeratosis as a consequence of hair cycle disturbance [7], [14], [55].
Thus, we conclude that TD myotubes possess intrinsic features that prevent full DNA replication and cause damage as a consequence of attempted DNA synthesis.
Infection appears to play a major role, either as a cause or as a consequence of PROM/PPROM.
