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The increasing number of individuals with cancer receiving potentially life-threatening treatments which have significant side-effects causes a considerable challenge for acute hospital services.
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The latter one causes a considerable reduction of health related quality of life and frequently is challenging in terms of treatment, requiring pharmacological (preventative medications) and non-pharmacological (cognitive behavioural treatment, physical therapy, counselling etc) approaches.
Antibiotics prescribed for selected indications causes a considerable alarm.
Accordingly, H2O2 treatment causes a considerable increase in mutation frequency.
Drought causes a considerable (~50%) annual yield losses.
The chloroplast genome serves as a valuable example of how the presence of large repeats can cause assembly error and would impose a considerable challenge to the de novo assembly of a genome.
However, the coexistence of semiconducting (s-) and metallic (m-) SWNTs remains a considerable challenge since the latter causes significant degradation in device performance.
Large bone defects caused by trauma, inflammation, tumor resection, or skeletal abnormalities are a considerable challenge to reconstructive surgeons.
Lodging is a considerable challenge for main crops during the growth as it often causes severe reduction in yields.
However helping children recover from the trauma caused by their experiences and ensuring their long term reintegration into their communities remains a considerable challenge.
Trauma is the leading cause of temporomandibular joint (TMJ) ankylosis, and the treatment of this condition poses a considerable challenge because of the high incidence of recurrence.
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