Hsp27 is stress-activated multifunctional chaperone that inhibits treatment-induced apoptosis and causes therapy resistance.
Further, CVL-dysfunction by itself or in combination with associated complications may cause therapy delays resulting in adverse outcome.
Despite encouraging results from preclinical studies, we have limited knowledge regarding mechanisms causing therapy resistance in vivo.
Adverse reactions were generally mild to moderate, only causing therapy discontinuation in three patients (two seizures, one rash).
The repopulation lag time after giving a radiation dose may obscure the effect of variations in tumour repopulation, which can cause therapy resistance [ 29].
In addition, although the safety profile of recent agents is quite superior in comparison to older medicines, the incidence of side effects, such as sexual dysfunctions, may cause therapy discontinuation, especially in younger patients.
'Probable' codes were defined as those specifying a likely symptom, cause, therapy, investigation or outcome of upper gastrointestinal haemorrhage.
DNA damage caused by therapies that disrupt cell cycle has direct immune stimulatory effects.
An accumulation of evidence indicates that CSCs can cause conventional therapy failure and cancer recurrence because of their treatment resistance and self-regeneration characteristics.
In fact, the devascularization caused by antiangiogenic therapy increases tumor hypoxia, and this hypoxia mediates resistance to antiangiogenic therapy [ 53].
