Sentence examples for caused substantial problems from inspiring English sources
Fine-grained, gritty ash caused substantial problems for internal-combustion engines and other mechanical and electrical equipment.
For these patients, skin discoloration, discomfort, and overall appearance of their left leg caused substantial problems (i.e., symptom severity ratings of 3 or 4).
While this constraint was not an issue for our longer gene sequence alignments, it caused substantial problems for more than half of the shortest gene sequence alignments.
Taken together, this causes substantial problems for fully automatic pipelines that aim to use these data comprehensively for studies of animal phylogenetics and the molecular evolution of mitogenomes.
On the other hand, MAF filtering of small lesions always causes substantial problems, independent of their target to background ratios.
This also implies that even a few dB of elevated SRT in HI listeners can cause substantial problems understanding speech compared to NH listeners.
The literature has documented that impaired activities in diabetic patients can cause substantial problems such as functional decline, dependency and physical disability [ 7, 22, 23].
Applying the model assuming HWE as a second pass should not cause substantial problems even if the true genotype frequencies do not conform to HWE.
While female donor leukocytes in a male recipient are not expected to cause substantial problems, it is reasonable to expect some issues with male donor leukocytes in female recipients because of the existence of unique proteins associated with y-chromosome gene expression [ 4].
