Sentence examples for caused substantial debate from inspiring English sources

However, not always has the application of remote sensing data analyses been rewarded with success, and the lack of diagnostic criteria has caused substantial debate in the past (e.g., Papagiannis 1989; Paillou et al. 2006a, b; El-Baz and Ghoneim 2007; Buchner and Schmieder 2007; Schmieder et al. 2008, 2013; Orti et al. 2008; Cigolini et al. 2012; Daneshvar 2015).

The effect on clinical trial interpretation when using these methods is not necessarily trivial, and has caused substantial debate regarding their usefulness and validity (Senn, 2000).

The international debate on medical decision-making at the end of life has caused substantial and profound differences of opinion between opinion leaders, different professions, the public and different countries.

The ICO had to demonstrate that nuisance callers caused "substantial damage or substantial distress".

But Environmental Advocates argued that it would have caused substantial harm.

The Great Recession has not caused substantial retirement delays.

Previously the ICO had to prove that a company caused "substantial damage or substantial distress" in making such calls or sending spam text messages.

The law currently requires the ICO to prove a company caused "substantial damage or substantial distress" by their conduct before action can be taken.

The explosion of the rocket caused substantial damage to the launch pad and facilities.

Cyclone Nancy caused substantial damage throughout the Cook Islands.

The head-on collision caused substantial front-end damage to both vehicles.