Sentence examples for caused significant challenges from inspiring English sources

In recent years, the economic downturn and the ageing town water and sewer infrastructure caused significant challenges to Chiredzi Town Council's capacity to provide clean water to its more than 30,000 residents.

The risks of emerging clean technologies quickly becoming obsolete are well recognised and cause significant challenges.

Norman Provan, associate director at the Royal College of Nursing, said: "In the case of a no-deal Brexit there would be no transition period which would likely cause significant challenges for the health and social care sector.

A towering pyrocumulus cloud has formed over the fire area, which will probably cause significant challenges for firefighters, said Capt.

This mentality is something that causes significant challenges in my line of work and often results in people developing significantly lower qualities of life.

However we still have significant challenges.

QPX challenge caused significant but transitory changes in hemolymph parameters that were obvious at 2 months but disappeared at 4 months.

Fig. 6A shows that the toxic METH challenge caused significant increases in BDNF in the presence of METH preconditioning.

A single-day toxic METH challenge caused significant decreases in TH protein expression in rats euthanized two weeks after drug injections (Fig. 3A).

The METH challenge caused significant decreases (−63%) in DA levels in the striatum of rats pretreated with saline (SM group) (Fig. 1A).

As seen in Fig. 4A, the METH challenge caused significant changes in HspB2 expression in both the presence and absence of METH preconditioning, with the increases in the METH preconditioned group being of greater magnitude.