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In the in vitro studies, we clearly demonstrated that APC caused sensitization of HCT-116 cells than HCT-116-APC KD) HCT-116-APC KD
The main result is that the network adaptation in the time scale >100 ms invariably caused sensitization (Fig 5C E); i.e. it increased the LMC output in all natural light-dark transitions.
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It is rare for a mother to become sensitized during the course of her first Rh-positive pregnancy because the amount of fetal Rh antigen that enters maternal circulation is insufficient to cause sensitization; usually only during labour will exposure be significant.
Inflammation causes sensitization of peripheral and central nociceptive neurons.
Critical levels of these substances are thought to cause sensitization and activation of trigeminal neurons in the afferent loop and, in turn, activate second-order neurons in the trigemino-cervical complex.
One reported hypothesis is that altered pain modulation due to nociceptive stimuli arising from pericranial myofascial tissues may cause sensitization in the trigeminal nucleus, thalamus, or somatosensory cortex [7].
Panel c shows peripheral sensitization after tissue injury, which results in the release of a number of inflammatory mediators (e.g., histamine, bradykinin, prostaglandins, interleukins, adenosine, and nerve growth factors) that, in turn, induce the expression of transient receptor potential (TRP) channels and cause sensitization of the peripheral nociceptor.
application of SP causes sensitization to heat in a similar fashion to the capsaicin-mediated thermal hyperlagesia described above.
Indeed, prostaglandins have been shown to cause sensitization of peripheral sensory neurons (peripheral sensitization) [6] and to produce allodynic behavior [7], [8].
In other mammals, SP plays an important role in nociception: it is released from C-fibers onto spinal neurons where it facilitates NMDA receptor activity and causes sensitization that can last for minutes, hours or days.
It however remains to be determined what causes sensitization in the Hep3B and HuH6 cell lines.
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