Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-mediated toxicity and short persistence of CAR T cells in vivo might limit the effectiveness of anti-CD19 CAR T cells.
Specifically, bariatric surgery causes remission of type 2 diabetes (T2DM) and cardiovascular diseases (CVD) such as hypertension.
In fact, a study published in the Journal of Feline Medicine and Surgery concluded that high-protein, low-carb diets are as or more effective than insulin at causing remission of diabetes in cats.
These results are consistent with a previous report showing that lentiviral vector-mediated HSV1-tk gene therapy can cause remission of cancer stem-like glioblastoma xenografts.
Pregnancy in mice, like pregnancy in women, normally causes remission of arthritis [ 5, 10], while exacerbation often occurs postpartum [ 7, 10, 11].
Although there is no clear consensus on the mechanisms that cause remission of diabetes, one common aspect among the varied bariatric surgeries is the improvement in insulin sensitivity [ 6, 7].
Cetuximab and trastuzumab have shown limited efficacy in causing remission in a proportion of patients with metastatic colorectal cancer and breast cancer respectively [ 21, 22], while trastuzumab has improved survival of women with ErbB2 positive breast cancer when given as adjuvant therapy after chemotherapy [ 32- 34].
Consequently, androgen deprivation causes remission or clinical improvement in a high proportion of locally advanced or metastatic prostate cancer.
In rats treated with 6-OHDA or MPTP, pinealectomy or suppression of melatonin synthesis by bright light caused a remission of symptoms [ 308].
The topical treatment with butenafine hydrochloride 1% for 4 weeks caused complete remission of lesions, with no recurrence during follow-up for 1 year.
