Sentence examples similar to caused on target from inspiring English sources

Moreover, navitoclax caused on-target toxicity in BCL-xL-dependent platelets, causing thrombocytopenia in CLL patients.

Ideally, TAAs are presented on tumor cells but not healthy cells, ensuring that TAA-specific T cells achieve antitumor effects without causing on-target off-tissue toxicity.

Certain toxicities are caused by on-target, mechanism-associated effects, which can be stratified by whether or not the targets are relevant to response.

This paper focuses specifically on data acquisition errors caused by target setup, acquisition, and reorientation.

The mantra was "on target, on trigger".

We hypothesized that the pro-LktA retains the ability to cause biological effects on target cells as has been reported in the case of the closely related RTX toxin α-hemolysin (HlyA).

HOTAIR acts as a molecular scaffold remodeling chromatin by causing histone modifications on target genes.

PM contains many toxic chemicals that are regarded as reactive oxygen species (ROS) (Lemaire and Livingstone 1997; Sun et al. 2006), which can cause oxidative damage on target tissues (Ames et al. 1993).

First, we evaluated whether inhibitors of glycosylation caused off-target effects on adenylate cyclase activity.

Anything on target caused them to shudder.

We have shown that the MTP lead compound 1 acts on target, causing DNA strand breaks in T. brucei but not in human HEK cells.