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Both doses tested (25 and 250 μg/kg) caused modification of the expression of similar clusters of genes (e.g. several differentiation markers, immune-related genes) that have also been reported as differentially modulated by BBP exposure in this work.
We injected aPC as a single intravenous bolus since administration by infusion would have needed the placement of a catheter in the anesthetized rabbits, and this procedure would have caused modification of the haemodynamic condition.
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However, inability to replicate these results caused modifications of the protocol in our series.
High DC biases were found to cause modification of the surface of any subsequently deposited film (either low or high density).
Finally, epigenetic events are those that cause modification of the genome without modification of the DNA itself.
Some of the proteins secreted by the nematode are injected into host cells and cause modification of the plant cells to form giant cells.
Rules marked as crucial receive special attention, not only during construction of the computational model but also later, during software development when infeasibility causes modification of the problem and removal of required rules (requirements).
Under these conditions there is an increased sympathetic adrenergic tone and reduced parasympathetic activity [ 3], a combination that causes augmented ventricular workload and oxygen demand, increasing the occurrence of ischemic events, and causes modification of the ionic currents across the cellular membrane, leading to direct electrical instability of myocytes.
However, the multiplication of SNCA has been also linked to the disease and polymorphisms that cause modification of the ASYN transcription have been shown to increase the risk for sporadic PD development, suggesting that even the Wild Type (WT) form of ASYN, if overexpressed, could contribute to the development of PD [ 4- 7].
Inter-female pheromones can also cause modifications of the oestrous cycle [ 12].
Thus, LMTs are more likely to cause modifications of the surface lignin, observed as changes in the adsorptions of cellulases, rather than to cause lignin dissolution.
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