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A second infection of transfected clones with Cre-recombinase adenovirus caused excision of the neomycin-resistant cassette.
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Thus, since Nestin-Cre causes excision of loxP flanked genes in neuronal and glial precursor cells, but Tα1-Cre mice are specific for postnatal neurons, it is tempting to assume that the cerebellar phenotype in Txnrd1-NS null mice is caused by disruption of Bergmann glia function and/or diminished proliferative capacity of granule cell precursors.
A viable mutant created by insertion of a P-element (EP578) had been described as a suppressor of reaper-induced cell death [25], and a small deletion caused by excision of the P-element was reported to have generated a lethal null allele of the traf4 gene, traf4ex1 (formerly traf1ex1 [26]).
One isolate had a large region (8,644 bp) missing, which was probably caused by excision of a prophage.
One intuitive mechanism to account for improved sexual functioning post hysterectomy is the relief from dyspareunia caused by excision of uterine pathology (i.e., fibroids, menorrhagia).
These results indicate that Cre-mediated recombination of the pBS-DS-hIgG vector caused the excision of floxed stuffer sequences and the expression of the hIgG complex as a whole antibody similar to trastuzumab for clinical use.
It further points to multiple events of KLK2 death through different genomic mechanisms: Unequal crossing-over between KLK3 and KLK 2 led to the loss of KLK2 and to the rise of a cKLK, whereas large deletions caused the excision of KLK2 and relaxation of selective constraints led to KLK2 pseudogenization.
Monsel's solution (20% ferric subsulfate) is used for hemostasis to wounds caused by excisions of skin.
In LinALL02, the seven amino acid C-terminal truncation is likely caused by imperfect excision of this IS6100 element.
The authors believe that there will be distal neurological deficit caused by the excision of schwannoma with fascicular involvement (75% of patients (6 out of 8)).
Such a break in AGR is caused by the excision of a transposon; therefore, the deletion derivatives of the element are newly synthesized.
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