Wang, E. A., Israel, D. I., Kelly, S. & Luxenberg, D. P. Bone morphogenetic protein-2 causes commitment and differentiation in C3Hl0T1/2 and 3T3 cells.
Geminin (HUGO approved symbol GMNN) is down-regulated in trophoblast giant cells and the ablation of geminin is sufficient to cause commitment of pluripotent inner cell mass cells to the trophoblast lineage [ 33].
We can use these data to calculate the effects of Pp on Δ[Vrn3]ap if we assume an arbitrary threshold of 1·0 to represent the [Vrn3] required to upregulate [Vrn1] enough to cause commitment to TS (Assumption 6 outlined in the Introduction).
Our additional study revealed the loss of CD34 expression in subsequent passages (result not shown), which can be caused by commitment of cells.
While charitable giving to Jewish causes, commitment to education and liberal voting patterns continue to distinguish Jews as a group, religious practice and affiliation are irrelevant to a significant percentage of them.
During 1799 a number of factors, including inadequate food production on Malta, lack of resources and troops caused by commitments elsewhere in the Mediterranean and the appearance of a French fleet under Admiral Etienne Eustache Bruix in the Western Mediterranean all contributed to lapses in the blockade.
Reaching out from their traditional Bismarckian policy of trying to balance east and west, the Germans have now identified their cause with commitment to the west.The French on the other hand have found their national revival in a more traditional appeal to patriotism.
For example, ask yourself if you lose high performers, generate unnecessary turnover, or cause reduced commitment and enthusiasm.
What causes such commitment?
A fundamental question of cell state switching is whether (i) an external signal that causes a commitment to the expression of a particular phenotype does so by somehow instructing the gene transcription apparatus to express the appropriate (set of) gene(s) in all cells, or (ii) the signal merely promotes survival and expansion of the few cells that "happen" to express that desired phenotype [25].
