However, especially "conventional" HSC isolation suffers from high levels of variation caused by the batch-dependent quality of the enzymes used for liver digestion, age, gender, genetic background, and the treatment of the mice [ 5].
The ability of the proposed method to suppress the inherent variation in the solubility caused by batch-to-batch parametric drift and handle the noise in post-batch measurements is demonstrated by applying the proposed parameter estimation and control method to a kinetic Monte Carlo (kMC) simulation model of a batch crystallization process used to produce hen-egg-white (HEW) lysozyme crystals.
Based on the consensus that there were significant effects, a second workshop was held to develop strategies to reduce the problems caused by batch-to-batch variation in estrogenic compounds in animal diets.
It released a safety notice saying: "As a precautionary measure AG Barr is withdrawing four batches of its Rubicon Sparkling Mango two-litre soft drink from the market because of signs of fermentation and the possibility that increased pressure caused by this fermentation may cause the bottle to burst.
When measurements of copy number are sufficiently imprecise as to form a continuously varying distribution (i.e. a bell-shaped distribution, rather than a distribution with discrete peaks at integers), these measurements will usually hide technical confounds caused by experimental batch effects, DNA-isolation batch effects and other unknown factors [ 50, 51, 53, 54, 57].
Some suspected that the mass sleeping was a form of mass psychosis, and others suggested that it was caused by a bad batch of vodka.
Some thought the symptoms were caused by a bad batch of "poppers" -- nitrate inhalants, widely used for a quick high in gay bars and clubs.
The two-time defending Nascar champion and Daytona pole-sitter Jimmie Johnson, the four-time series champ Jeff Gordon, Dale Earnhardt Jr. and Casey Mears were forced to change engines because of a lifter problem probably caused by a bad batch of coating.In all, five of the nine Hendrick-powered cars had problems.
The innovation introduced is an analytical model able to consider frequent set-ups, such as those caused by batch switching.
The press also reported that these incidents were likely caused by "a bad batch of street level drugs".
