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The complexity of neuronal circuits presents a challenge when investigating potential future treatments for diseases caused by central nervous system defects.
PID comprises a group of rare, inherited disorders of the immune system caused by defects in the development and/or functions of the various cells of the immune system leading to impaired adaptive and/or innate responses, predisposing patients to infections, allergy, autoimmunity and cancer.
Primary immunodeficiencies (PIDs) are a group of diseases caused by inherited defects of the immune system, in which the common hallmark is the susceptibility to infection.
It is caused by elevated levels of the neurotransmitter glycine in the central nervous system, which in turn are caused by a defect in the enzyme system responsible for cleaving the amino acid glycine.
These results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system.
To determine if the swollen phenotype was caused by defects in the excretory system, as described for Smed-egfr-5 RNAi) animalSmed-egfr-5 RNAihe Smed-egfr-5 RNAie specific protonephridianimalser carbonic anhydrase (CAVII-1)25.
The synaptic defects in ttx-7 mutants might be caused by defects in a selective transport system of synaptic proteins.
Dr. Kaplan wrote several technical books on heart disease caused by birth defects; Hodgkin's disease; and cancers of the lymph system.
We have previously shown that SAFB1−/− mice display both prenatal and neonatal lethality, growth retardation (caused by defects in the IGF signaling system), infertility in male mice and reduced testis weight (Ivanova et al., 2005).
The syndrome can also be caused by heart defects.
Certain inherited diseases of the skin and the lungs are also caused by telomerase defects.
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