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Importantly, repeat length determines in large part the severity of the diseases caused by expanded repeats4.
Moreover, the design of double layer matrix can make the absorption peaks shift to lower frequency, which can be attributed to the multiple scattering and reflections of incident wave caused by expanded perlites.
Friedreich's ataxia (FRDA), which is characterised by neurodegeneration and cardiomyopathy, is caused by expanded GAA repeats within the gene encoding frataxin, a conserved mitochondrial protein.
Taken together, these data indicate that suppression of Ataxin-3 protein cleavage may significantly slow down the progression of neurodegeneration caused by expanded Ataxin-3 protein expression.
HD is caused by expanded polyglutamine cytosine-adenine-guanine (CAG) repeat sequence in the autosomal dominant gene that encodes huntingtin (Htt, 4p16.3) [ 8].
Thus, the down-regulation of genes may involve multiple mechanisms in addition to the down-regulation of CREB target genes; further investigations on the mechanisms underlying transcriptional dysregulations caused by expanded polyQ stretches should be carried out.
Similar(48)
It is also found that the human-induced reduction in inflow to the sea changed over time, reflecting the changes in irrigation water demands caused by expanding irrigated areas and changing climate conditions (both inter-annual as well as inter-decadal variabilities).
The population is, however, gradually decreasing due to habitat loss, caused by expanding human settlements and poaching for its superior meat.
True differences, when intracranial gradients are caused by expanding masses or unilateral hemorrhages, call for clinical judgment.
Therefore, we concluded that the pattern was real and caused by expanding the pI (4-7) on same length of IPG strip as 3-10 pI.
Its reason was postulated as that the lymphatics in the tumor tissue were destroyed by invaded tumor cells, or high interstitial fluid pressure caused by expanding tumor cell masses and growing malignant cells in a confined space [ 18].
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