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This lack of activity is caused by an evolutionary conserved sequence divergence of a key non-consensus residue located in its PTP motif 9, since its back mutation specifically reactivates HD-PTP tyrosine phosphatase activity against DiFMUP.
We found that HD-PTP tyrosine phosphatase inactivity is caused by an evolutionary conserved amino acid divergence of a key residue located in the HD-PTP phosphatase domain since its back mutation is sufficient to restore the HD-PTP tyrosine phosphatase activity.
We hypothesize that these inconsistent dating estimates across the tree could be caused by an evolutionary rate acceleration of HIV-1 after entering the Slovenia epidemic that is not taken into account by the molecular clock model.
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This effect may be caused by an accelerated evolutionary rate in some families which are more prone to gene duplication and/or retention than others, e.g. due to their function or base composition.
We consider this fusion or insertion of a domain to be caused by a single evolutionary event.
We ascribe this higher accordance of selected features by SANN/LDA and GA/MLHD to a more extensive variable combination caused by a similar evolutionary algorithm of both methods compared to greedy/LDA.
This simple structure falsely points to a low genetic diversity: Spirogyra is commonly excluded from phylogenetic analyses because the genus is known as a long-branch taxon caused by a high evolutionary rate.
Such a functional divergence might be caused by an increase in evolutionary rates in one ortholog, by changes in expression, regulatory evolution, insertion of repetitive elements, or due to positive Darwinian selection in one copy.
This scaling effect in the Dependent model is caused by a change in evolutionary pressure associated with a particular phenotype.
This is expected as real data is more likely to fall along a continuum caused by a mixture of evolutionary processes, rather than fit yes/no definitions for the adaptive radiation metaphor [ 71].
To put it another way, all formulations of the Tree of Life hypothesis have at their core the basic tenet that the pattern of diversity that we see on the planet is caused by a tree-like evolutionary process and the differences in these formulations is to be found in how much they allow deviation from this central idea.
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CEO of Professional Science Editing for Scientists @ prosciediting.com