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Hence the origin of the elevated activity of the 5B isoenzyme reported previously [ 28, 29] and confirmed in the present study with the equivalent ΔROX1ΔCOX5A strain must be caused by a secondary effect.
The tau accumulation might be caused by a secondary effect of αsyn accumulation, such as dysfunction of cellular activity [ 43, 44] or abnormality in protein degradation machinery [ 45]. Biochemical analysis clearly showed that accumulated αsyn was phosphorylated and ubiquitinated similarly to that in DLB brain, regardless of injection site.
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When the protagonist diffuses this with his move called 'gale'; this causes a secondary effect.
Gf dominated the drag variations, with Gr only causing a secondary effect.
The changes of mRNA abundance observed in this study could be caused by indirect (secondary) effects, for example, disturbed mRNA degradation of transcriptional factors could increase or decrease mRNAs which transcription is regulated by those factors.
Second, the data argue that the reduced presynaptic release caused by vGlut2 overexpression is not a secondary effect whereby vGlut2 overabundance disrupts the vesicle fusion apparatus, since release can be precisely potentiated at this NMJ.
However, it is still not clear whether the inflammatory response found in AE skin is a primary basic cause of the disease, or if it is a secondary effect caused by other factors such as an impaired skin barrier.
24 It should be noticed that we observed the highest increase in proportion of IL-10-producing cells within the regulatory B-cell population, thereby providing evidence that the increased IL-10 production by total B cells is not simply a secondary effect caused by changes in peripheral B-cell distribution patterns, but instead, that Fingolimod has a direct impact on regulatory B-cell functions.
However, an indirect involvement of SCG10 cannot be ruled out as this can be due to a secondary effect caused by its direct interactors.
Therefore, we believe a change in the expression levels of this family maybe due to a secondary effect caused by DAC treatment, such as the up-regulation of specific transcription factors.
The observed increase in medulla content in thymi of ADAM8−/− mice is thus likely a secondary effect caused by the elevated number of mature T cells that are present in ADAM8−/− thymi.
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