Among these, three (OsPYL11 13) are thought to be nonfunctional that were caused by a large fragment deletion in the N or C terminal of the gene (Kim et al. 2012).
We previously showed that HD mouse models have elevated IKKβ/NF-κB in the CNS, and blocking IKKβ activity prevents degeneration of medium-sized spiny neurons caused by a toxic fragment of mutant Htt [18].
Several residues appeared to be affected in nearly every sample; indeed, small peak shifts were observed in the negative control sample (Δ Tm=+0.1 °C) for Asp 76, Ile 133, and Ala 149, which are presumed not to be caused by a direct interaction with the fragment.
A significant photo-stabilising effect towards photo-destruction of polyacrylonitrile was found, which might be caused by a possible "synergism" of two stabiliser fragments differing in their action.
In the film, the fragments are caused by a Russian anti-satellite test gone wrong -- but could this happen in real life?
Therefore, to reduce any possible bias caused by difference in fragment lengths between samples, fragment length normalisation was performed using a custom perl script.
This indicates that it is possible to distinguish between the global load effects and the local damage effects that are caused by the fragment impacts.
Crockard et al. [ 54] presented a series of 16 cases with delayed presentation of myelopathy due to odontoid nonunion and central spinal stenosis caused by odontoid fragment dislocation.
The availability of MS ameliorates but does not completely eliminate the difficulties in de novo sequencing of complete peptides caused by missing fragment masses and high-intensity noise peaks.
Three different myoA tail sequences were prepared (terminating at Leu 805, Leu 804, and Ser 803); by analysis of residue-specific CSPs caused by the fragment and the crystal structure of the wild-type complex with PfmyoA 799 818), it was rationalized that these positions should provide enough space for the fragment to adopt a binding conformation.
