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Mitochondrial encephalopathies are fatal, infantile neurodegenerative disorders caused by a deficit of mitochondrial functioning, for which there is urgent need to identify efficacious pharmacological treatments.
No Labels -- an organization that earnestly believes that all of America's problems are being caused by a deficit of niceness among Congresscritters -- really wants them to agree to bipartisan seating at the upcoming State Of The Union address.
No Labels, a bipartisanship advocacy group that The Huffington Post's Jason Linkins recently described as "an organization that earnestly believes that all of America's problems are being caused by a deficit of niceness among Congresscritters," has been among the biggest proponents of the new decorum.
A similar feminization of the X has been observed in many fly species (Sturgill et al. 2007; Vicoso and Bachtrog 2015), and found to be largely caused by a deficit of testis expression for X-linked genes.
Mucopolysaccharidosis type II (MPSII or Hunter Syndrome) is a monogenic, X-linked inherited lysosomal storage disorder (LSD) caused by a deficit of the iduronate 2-sulfatase (IDS) enzyme, involved in glycosaminoglycan (GAG) catabolism.
All these features are reminiscent of a retrograde phenotype, usually caused by a deficit of either the IFT dynein or the IFT-A complex (Pazour et al., 1998; Ou et al., 2007; Absalon et al., 2008a).
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The apoptotic phenotype in SpRunt-1 deficient embryos is specifically caused by a deficit in the expression of SpPKC1, a direct regulatory target of SpRunt-1 that encodes a conventional protein kinase C [ 8].
Although glucose-mediated lipogenesis was severely affected by SCD1 inhibition, several lines of evidence suggest that the abnormally low cell proliferation rate in SCD1-ablated cells was not caused by a deficit in the availability of glucose or the glycolysis-derived products.
Suicide rates have risen significantly since the financial crisis began, but to say that suicide is caused by a deficit in serotonin is kind of crazy".
A mouse model with a duplication syntenic to human interstitial duplications of 15q11.2-q13, displayed behavioral deficits characteristic of autism, possibly caused by a deficit in 5-HT2c receptor signaling (Nakatani et al., 2009; Tamada et al., 2010).
We have shown in a previous study (Iglesias et al., 2011) that MMOs are caused by a relative deficit of sodium current with respect to potassium current, which is due to a slow sodium inactivation.
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