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On the other hand, CT166 seems to be biologically highly potent, e.g. concluded from the observation that the repressed but leaky expression system caused already almost complete cell responses.
This is slightly below the surface burden threshold proposed by Tran et al. and caused already inflammation and retarded clearance in the lung.
In contrast, in MEF expressing different oncogenes, Chk1 inhibition per se caused already some cell death, and combination with IR was most effective in cell killing (Supplementary Figures S3 and S4), similar to findings made in HeLa cells where DNA damage and Chk1 inhibition were shown to integrate on the formation of the PIDDosome and Caspase-2-dependent cell death.
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In some cases, migration causes already dysfunctional families to implode.
First, it causes already uncontrolled health care costs to rise even more due to increased, unwarranted doctor's fees.
That tremendously increases the difficulty and cost of obtaining financing, and causes already nervous suppliers to demand immediate payment.
Even without stirring, the reactor internals cause already interaction between the gas and the liquid, resulting in a mass transfer coefficient amounting to 1.17 × 10−2 s−10−2
In August, Wolfe himself was bedridden, causing already low morale to slump even further among the British troops.
Austerity is a pro-cyclical policy that makes a recession or depression worse by causing already inadequate demand to become even more inadequate.
Many other factors can cause already vulnerable households to be even more at risk from the effects of malaria and influence the pursuit of treatment.
This is a fairly common ingredient in many commercially produced shampoos, but it can cause already weakened hair to further shrink and break.[1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com