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Supporting the possibility that p16 translation initiation was suppressed by miR-24 are data showing that a reduction in miR-24 function by AS-miR-24 caused a modest shift in p16 mRNA towards heavier polysomes (Fig. 7D).
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The D65V substitution also causes a modest shift in nearby loops, which results in the optimization of electrostatic contacts at nearby residues.
Knockdown of either isoform caused a modest but significant reduction in the magnitude of phase shifts.
In preplaque mice, β1 formed a complex with Aβ that caused a modest Aβ increase in brain and plasma.
Contact with a treatment user caused a modest increase in stigma (standardized effect size = 0.15, p = 0.03).
Nitrate replacement caused a modest but significant inhibition (−15.5±2.8%, N = 9; P = 0.0006).
IL-1β caused a modest reduction in the mIPSCs.
In contrast, L51A and E82A had little or no effect while E82K caused a modest reduction.
Mutation in Cdc27 (causedL71123) caused a modest reduction in differentiation and no visible change in growth.
GEF16 also caused a modest activation of Rac1 and no activation of RhoA.
RO28-1675 caused a modest dilation in arteriole but not contractile sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com