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If the coupled-oscillator theory is true for the cow, this may have caused a counteraction mechanism, masking any effect on the cycle length.
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This unphysiologically long stimulation causes an endocrine counteraction: GnRH analogues in this regard are a homogenous class of medicines exerting their effects by de-sensitization of receptors in the anterior pituitary gland rather than by single substance effects.
As a counteraction effect to the selective pressure for susceptibility to atherosclerosis, natural selection may have caused a permanent down-regulation of these genes in the SUS individuals to decrease endogenous cholesterol synthesis to maintain homeostasis.
It caused a furore.
Caused a traffic accident?
"This caused a panic".
It caused a sensation.
It caused a storm.
That caused a stink.
That caused an uproar.
She caused an uproar.
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