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Any attempt to engineer genomes by invasive methods can cause unexpected effects.
This might well be complicated: nano-particles might reach parts of the body that are inaccessible to the soluble material and thus cause unexpected effects.
Elevated CO2 alone tends to favour dominance by CO2-responsive species yielding a more CO2-responsive ecosystem (Arp et al. 1993; Newton et al. 2014; Polley et al. 2014), but addition of N can cause unexpected effects mediated by plant community shifts (Fig. 1; Langley and Megonigal 2010).
Despite the relatively low estimated doses from eating any one food, these authors and others, point out there are multiple sources of intake of BPA, and evidence increasingly suggests that BPA and other endocrine disruptors like the hormones they mimic may cause unexpected effects even at tiny doses, although the extent to which these effects may occur in humans is still under investigation.
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Our results indicate that transgene expression in GM citrus remains stable during long-term agricultural cultivation, without causing unexpected effects on crop characteristics.
Liver-specific transgene expression is crucial to avoid side effects when the liver is targeted because the transgene expression in nontargeted organs may cause unexpected side effects.
Drug treatments that interfere with feedback regulation can cause unexpected adverse effects.
Elution of the remaining matrix material during subsequent analysis can cause unexpected matrix effects resulting in significant ionization inefficiencies.
Hyaluronate, a main component of glycosaminoglycans, provides CD44-specific interactions with chondrocytes but typically requires chemical cross-linking agents to fabricate hydrogels, which may cause unexpected side effects in the body.
They can interact with various 'off-targets' besides their designated targets, which may cause unexpected side effects.
The use of CD19L sTRAIL higher dose levels and prolonged schedules may cause unexpected side effects alone and/or in combination with low dose TBI in clinical settings.
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CEO of Professional Science Editing for Scientists @ prosciediting.com