Exact(5)
An important milestone in future will be to fully understand the mechanisms that cause the altered state of the signaling network and to identify efficient strategies to maintain them in a more in vivo-like state.
Although wild-type and mutant strumpellin co-localised with both proteins, expression of disease mutant strumpellin did not cause the altered subcellular distribution that we observed after strumpellin depletion (Fig. 8E H).
Death of a significant number of RGCs that project to a specific region could cause the altered segregation pattern evident in Chrnb2−/− LGN.
However, a caveat with all in vitro studies, it cannot be excluded that further disruptions may occur downstream from the intracellular calcium signalling events to cause the altered protein and fluid secretion seen in vivo.
An important question is how might changes in FGF-2 concentration or the absence of HS co-receptor cause the altered phosphorylation kinetics of FRS2 and p42/44 MAPK and so change the biological outcome of FGF signaling.
Similar(55)
Therefore, the possibility of an altered proliferation rate causing the altered appearance was explored, potentially causing the cartilage to appear more cellular.
The aim of this work was to characterise ASC in comparison to MSC in order to identify genes which may be involved in mechanisms causing the altered chondrogenic potential of ASC.
To confirm that disruption of Rv0431 caused the altered immune responses in macrophages, and to rule out effects due to secondary mutations, expression of Rv0431 was restored in Tn Rv0431 by complementation using the predicted promoter upstream of Rv0430.
However, the reduction in progesterone could be causing the altered GnRH pulsatility, because progesterone is a well-known regulator of GnRH pulse frequency (Marshall et al. 2001).
Due to the petaloid character of this extra whorl of sepals and the expression level of CvAP3 in whorls II and III, it is concluded that only the lack of CvPI expression is causing the altered flower architecture and not a combined dysfunction of CvPI and CvAP3.
Adding ND may cause the altering of the degradation and combustion mechanism of polymer and reduce the production of smoke particles.
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