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The VGluT2 immunostaining was significantly reduced and this was associated with alterations in the synaptic integrity, and synaptic number per Purkinje cell with only a single exposure on PN4 enough to cause the alterations.
Thus, these SNPs' marked effects on β-cell function are very likely to cause the alterations in fasting plasma glucose levels seen in this and earlier studies [21]; [21].
Extracellular signals cause the alterations in gene expression and metabolism in cells via signal transduction.
The presence of V in the bone might lead to mobilization of Mg and Ca from this tissue and cause the alterations observed.
The tamponade with silicone oil for more than 9 months will cause the alterations of retinal saturation and the narrowing of retinal arterioles, which may further interfere with the oxygen metabolism in the retina.
The predominant activation of the MR at a low CORT level and additional activation of the GR during increased CORT level could cause the alterations of neuronal integrity and functions responding to stress, such as changes in neuroendocrine regulation and behavior [ 36].
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We also found that rs10801935 in intron1 may cause the alteration of the pre-mRNA secondary structure as predicted by RNAstructure 4.5 software [ 17].
In the other, the patients were not under deep sedation; therefore, voluntary muscular activation may have occurred that could have caused the alterations.
Despite the potential diagnostic value of Cho-containing compounds, the underlying mechanisms causing the alterations in Cho metabolism are not fully understood [ 23].
Also, ketamine causes the alterations of histone deacetylase (HDAC) activity and (BDNF) brain-derived neurotrophic factor in the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens [ 35].
During the inspection, the S.E.C. said, the director of Finra's Kansas City office "caused the alteration" of three documents detailing staff meeting minutes.
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