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Both pathways cause the activation of initiator caspases, which then activate effector caspases [ 21].
In addition, Syk can also motivate the NLRP3 inflammatory complexes under the action of ROS generated by ERK, cause the activation of Caspase-1, and change the ProIL-1β into the activated form, IL-1β [ 9, 35, 36].
Pathogenesis of pain via neural-glial interactions: We investigate (1) how neural signals (e.g., electrical activity and release of proteases) in primary sensory neurons cause the activation of glial cells (microglia and astrocytes) in the spinal cord after tissue and nerve injury, and (2) how glia mediators (e.g., cytokines and chemokines) modulate spinal cord synaptic transmission.
Of particular – yet unresolved – interest is how these nanoparticles cause the activation of these pathways.
The most common mutations in acute myeloid leukemia (AML) are those that cause the activation of FMS-like tyrosine kinase 3 (FLT3).
The data support the hypothesis that SO2 derivatives could cause the activation of proto-oncogenes and inactivation of tumor suppressor genes and SO2 derivatives may play a role in the pathogenesis of SO2-associated lung cancer.
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In contrast, our results clearly show that ASK1 activated by BSO causes the activation of JNK and p38.
The caspase activity results show that ESE-16 causes the activation of caspases and reveals that ESE-16 causes cell death in a caspase-dependent manner.
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2.
One of those counts said that by attempting suicide Manning had caused the "activation of the Force Cell Move Team" – the disciplinary crew of prison officers who are deployed forcefully to remove inmates from their cells.
Thus, our hypothesis is that, in those cells expressing A2ARs, cocaine causes the activation of A2ARs and STEP that contribute to its synaptic effect.
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