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Brucellosis itself yields low mortality rates, but it can cause substantial disabilities and weaknesses to the human immune system [ 9].
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Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder.
They cause substantial disability amongst those affected and impose secondary burdens on their families and work colleagues [2].
Both headaches cause substantial disability for patients and their families as well as to the global society due to very high prevalence in the general population [4].
Recurrent episodes and mood instability cause substantial disability and so prevention of severe episodes and mood stabilization are important therapeutic targets.
Our objective has been to secure among these diseases the rightful inclusion of migraine, tension-type headache (TTH) and MOH: headache disorders that we know cause substantial disability [3].
T2DM can lead to numerous micro- and macro-vascular complications and may cause substantial disability.
This disorder, which might be regarded as a complication of either migraine or TTH (and should therefore be included in the reckoning of both), undoubtedly causes substantial disability.
It is well established that headache causes substantial disability worldwide [1] and is among the most commonly reported neurological disorders in primary care [2].
CFS/ME causes substantial disability [ 2], and is associated with high levels of resource use [ 3].
Chronic low back pain (LBP) is a poorly understood condition causing substantial disability and health care costs worldwide [ 1- 4].
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