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This loss of federal money would cause single parents -- mostly mothers -- in New York State to lose more than a billion dollars in child support over that period, unless state taxpayers cover the cost of the program themselves.
Mitochondrial failure has been suggested as a probable causative factor because DOX interacts with mitochondrial enzymes to induce highly reactive oxygen species (ROS) that immediately target nearby mitochondrial structural components including DNA to cause single and double strand breaks (SSBs and DSBs) [2], [3].
Oxidative stress is known to cause single strand breaks in DNA [ 7].
Oxygen radicals cause single strand breaks in DNA and modify DNA bases.
In this study, we focus our analysis on the missense non-synonymous variations that can cause single amino acid polymorphisms.
Twenty-two unique mutations that cause single amino acid alterations in the MxA protein were chosen for the analysis.
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The in-orbit observations show that the typical SEU rate at Alsat-1's orbit is 4.04 × 10−7 SEU/bit/day, where 98.6% of these SEUs cause single-bit errors, 1.22% cause double-byte errors, and the remaining SEUs result in multiple-bit and severe errors.
The deepest areas of the oceans have pressures of up to 120 MPa, greater than the pressures known to cause single-chain proteins to undergo pressure-induced denaturation [9].
Recently we have reported that single wall carbon nanotubes (SWNTs) can induce a sequence-dependent B-A DNA transition [37], selectively induce human telomeric i-motif DNA formation [38], accelerate S1 nuclease cleavage rate [39], cause single-stranded poly rA) to form a duplex structure and bind to human telomeric i-motif DNA under molecular-crowding conditions [40], [41].
Thus, of nine reported missense mutations, six cause single-amino acid substitutions in the BIR2 domain.
Retrotransposition occurs de novo in the germ-line and can cause single-gene mutations that result in disease, an example being hemophilia A [ 4].
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