Two recent examples of clinical adverse effects which caused significant safety problems in large numbers of individuals, were osteonecrosis of the jaw with bisphosphonates and increased risk of myocardial infarction following rofecoxib use.
The wind power is totally dependent on wind flow, due to randomness and uncertainty of wind flow, the wind power generation is quite fluctuating in nature and large scale wind farms may cause significant impact to the power system safety, quality and stability.
As 17% of major accidents in the chemical industry occur during the storage process and cause significant losses, it is essential to improve safety in such installations.
The application of de-icing salts or atmospheric marine exposure is shown to cause significant long-term deterioration and reduction in structural safety.
Landscape disturbance from military training maneuvers can cause significant on-site deterioration that may impair ecosystem functioning, reduce training realism, and jeopardize the safety of soldiers and equipment.
Furthermore, this safety profile shows that addition of the PEG molecule to filgrastim did not cause significant qualitative changes in the filgrastim pharmacology/safety profile and no off-target toxicities were identified.
As the draft goes much further than any existing state or federal law, it's likely to cause significant controversy and could create a complicated patchwork of differing state laws that erode, rather than enhance, aviation safety.
Because HeV and NiV can potentially cause significant morbidity and mortality in humans, with consequent major economic and public health impact, they are classified as biological safety level-4 pathogens.
These geometric discontinuities cause significant stress concentrations.
Respiratory viruses cause significant morbidity and mortality.
