Interactions between process units (e.g., material recycle and energy integration) often cause significant difficulties in plantwide control.
The poor quality of communication between professionals, perhaps reflecting a limited understanding of the various roles in patient care, we found to cause significant difficulties.
In cheese factories, delays to fermentation can cause significant difficulties in a process that is based on a perishable starting material (milk) that cannot be stored in the event of delay.
In the Affymetrix systems the signal from one badly designed probe, which may be based on inaccurate data from a sequence database, can be easily eliminated from further analysis [ 41] without significant decrease in the precision of gene expression estimate, while in the Agilent systems the same design glitch might cause significant difficulties in the evaluation of gene expression levels.
However, Stausberg et al. demonstrated that the agreement in coding decreased when more detailed (for example five digit versus three digit ICD-10) codes were used and concluded that very detailed classification and complex coding rules for ICD-10 diagnoses cause significant difficulties even for coding experts [ 30].
This phenomenon, in fact, causes significant difficulty for perfumers.
The charter provided for the college to operate at both Canonsburg and Washington, a position that caused significant difficulty for the administration trying to rescue the college amid ill feelings over the unification.
This project has in recent years inadvertently caused significant difficulties in forming a stable, collaborative, national government, a stasis that grieved his generation.
This causes significant difficulties with the convergence of finite element solutions.
Later the same year, Scotland's Chief Inspector of Constabulary warned the sheer scale of Ore was causing "significant" difficulties for forces.
