Sentence examples for cause significant breakdown from inspiring English sources

By using LI-CM we intended to mimic the in vivo condition of late-stage pathology, when gliomas cause significant breakdown of the BBB (Wolburg et al., 2012); as a consequence, circulating immune cells not normally found in the CNS invade the tumor and release factors promoting the pro-inflammatory activation of glioma cells (Zhan and Lu., 2012).

Any failure in any of the pieces of the location system, e.g., breakdown of receivers, can cause significant problems when used in a real system.

It can cause significant distress, depression and can possibly lead to the breakdown of relationships", she added.

Neither cause significant visual loss.

"It can cause significant suffering for animals.

The depression did not cause significant damage.

Fluctuation in rates can cause significant differences.

A cut in the number of Crown Prosecution Service lawyers of almost 25%, coupled with rising administrative errors in the courts, has triggered fears that budget reductions are causing a significant breakdown in the criminal justice system.

There have been many breakdowns in security or privacy causing significant, and even irreparable, damage to companies' reputations.

It caused significant economic loss.

Neither caused significant damage.