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Surprisingly, a 2-h exposure to increasing concentrations of the synthetic ligand THIQ did not cause sequestration of either wild-type MC4R, Rm1, or Rm2 (Fig. 6A, B, C), even though similar concentrations of THIQ activated both Rm1 and Rm2 as measured by cAMP accumulation (Fig. 3).
Ceramides cause sequestration of Akt2 and activation of gluconeogenic enzymes (Fig. 4), although no relationship with in vivo insulin resistance could be demonstrated in humans (49).
Furthermore, a milder form of infection which usually follows exposure of immune individuals may still attain enough viral loads to cause sequestration.
Furthermore, our data obtained in cultured cells, transgenic mice and human post-mortem tissue indicate that in addition to the loss of its own nuclear function, FUS aggregation might cause sequestration of paraspeckle components into pathological inclusions.
Gene knockouts leading to extensive autosomal asynapsis, such as Spo11 −/−, can cause sequestration of the silencing machinery to a fraction of asynapsed autosomes and creation of pseudo-sex body accompanied by aberrant expression of sex chromosomes and stage IV pachytene arrest (Mahadevaiah et al. 2008).
Similar(55)
There is 0.9 cm of rightward subfalcine shift, with effacement of the posterior horn of the left lateral ventricle, thus causing sequestration of the ipsilateral temporal horn.
Afforestation is known as an available mitigation activity to climate change because it causes sequestration of CO2 from the atmosphere and stores it as the living biomass and the dead organic matter.
Silliman et al. proposed a nonimmune model based on two hits: first, a lung injury in the lung epithelium causes sequestration of neutrophils in the lungs, and second, the transfusion of blood storage causes liberation of cytotoxic factors and capillary damage.
This in turn causes sequestration in intranuclear inclusions, possibly leading to a progressive cellular defect in arginine methylation and chaperone activity.
In vivo treatment with fingolimod (FTY720), a drug that causes sequestration of T cells in lymph nodes [18], was used to further characterize T-cell redistribution to Ag-free lymph nodes.
PfEMP1 is a major adhesin that mediates binding to a variety of host-receptors causing sequestration of IEs in the microvasculature of various organs and severe disease in children and pregnant women.
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