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Moreover, activation of the metabolic regulatory network downstream of mTOR complex 1 (mTORC1) has been demonstrated to cause reprogramming of the essential metabolic pathways, including glycolysis, glutaminolysis and the PPP.
We hypothesize that environmental factors, positively affecting BW and/or negatively affecting social status, might cause reprogramming of physiological and social trajectories of affected individuals.
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We attempted to reverse potential epigenetic effects, by subjecting female-sterile evolved strains to various treatments known to cause or very likely to cause the reprogramming of gene expression [ 40, 41].
Nematodes establish complex interactions with hosts, and, upon successful infection, cause the reprogramming of host cell developing structures as multinucleate giant feeding cells.
TBT exposure causes transgenerational reprogramming of MSCs to favor the adipocyte lineage.
Therefore, the authors suggest that HPV16 expressionion causes epigenetic reprogramming of host cells at the level of histone methylation.
Therefore, altered signalling persists and potentially causes a reprogramming of the cell, including nuclear factor-kappaB activation.
This is supported by the fact that RNAi-based downregulation of the expression of FL-L1s as well as the inhibition of RT in transformed cells causes the reprogramming of chromatin segments to a more compact state in their derivates [ 30, 38].
Acting upon insights gained by the genomic road map will require a deeper understanding of how specific mutations cause tumors through reprogramming of signaling, metabolic, and epigenetic networks, particularly with regard to identifying therapeutic vulnerabilities (Cloughesy et al., 2014).
We suggest that these findings are attributable to the altered afferent input from the GHJ, which causes a central reprogramming of the cortical excitability and representation of the DM.
IAV infection causes a global reprogramming of the host SUMOylation landscape, the specific temporal dynamics of which have yet to be fully explored.
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