The introduction of five replacements, A11V, V23L, M25V, V44I and V58L, resulted in an increase of 16% in the overall volume of the side-chains forming the hydrophobic core but caused no remarkable changes to the positions of the backbone atoms.
Full-length Tat and the two truncated variants displayed similar distribution patterns with a slight decrease in nuclear localization of the truncated forms, and MG132 caused no remarkable changes.
Compared with air-fired combustion, high concentrations of CO2 and H2O in the flue gas cause a remarkable change in the pulverized coal combustion and heat transfer characteristics in furnace.
Further increase in concentration (beyond 500 ppm) did not cause any remarkable change in the inhibition efficiency.
The addition of silica nanoparticle can cause a remarkable change for the zero-shear viscosity and relaxation time.
On the other hand, the increase in the average power at a constant peak power causes no remarkable change in the ion-to-atom ratio, but the overall magnitude of the number of metal ions and atoms and gas temperature around the substrate increase obviously.
A change from a non-aromatic polar serine to cyclic and non-polar proline causes a remarkable change in the chemical and physical properties of the protein.
Mifepristone caused a remarkable change in cell shape, loss of cortical actin and stress fibers, and gain of peripheral membrane ruffles rich in polymerized actin.
ZnO nanoparticles also caused remarkable transcriptomic changes in terms of number of genes and their expression.
