The overexpression of Shb also causes reduced in vivo tumor growth of PC3 cells.
In turn, DAX-1 represses aromatase through its recruitment within the SF-1/LRH-1-containing region of the aromatase promoter, causing reduced in situ estrogen production and inhibition of cancer cell proliferation.
A disadvantage is that, at higher field strengths (e.g. 3 T), inhomogeneity in the B1 field may cause reduced signal in parts of the image and thus less contrast enhancement, which in turn may cause false-negative image interpretation.
Late mobilisation can cause reduced strength in internal rotation and thus early mobilization could be an advantage.
In neurons, mitochondria undergo fission perinuclearly in the cell body and are transported along microtubule or actin bundles [24], and global disruption of microtubule-dependent transport may cause reduced mitochondria in the axons and dendrites.
These results suggest the possibility that cross-inhibition of BACE2 by BACE1 inhibitors might cause reduced pigmentation in humans.
For instance, it has been shown that infants with neuromuscular diseases, which cause reduced movement in utero, have long bones which are thin, hypo-mineralized and prone to fractures [3].
However, similar mutations in other Aux/IAA genes cause reduced auxin responses in some tissues and increased responses in other tissue types [ 31- 38].
In leaves, jag mutations cause serrated margins, and in floral organs cause reduced growth preferentially in the distal region.
Alterations of the TM domain, like in the case of alternative splicing-deleting exon 6, will cause reduced mFAS expression in the detriment of sFAS.
