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Moreover, in rare cases, the live vaccine itself can cause polio.
The live oral polio vaccine did cause polio in a handful of cases and has not been used in the UK since 2004.
An early scare in America, where the vaccine had been rushed to market so hastily in some cases it still contained enough live virus to cause polio, had not helped build enthusiasm.
These virulent strains could cause polio in unvaccinated people, says Yoshida.
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The virus that causes polio spreads through what is politely known as the "faecal-oral route".
Now, there has been no atmospheric nuclear fallout since Chernobyl in 1986, fluoride is now an obsession only with the green ink brigade and the virus that causes polio could be one step from extinction.
For ten months, the program followed patients at Duke in a Phase I trial of an immunotherapy made from the virus that causes polio, genetically altered so that it could infect only tumor cells, not healthy tissue.
It is a fascination, he explains, with origins in his Welsh childhood (like most of Cale's fascinations): secrecy over reports by "Her Majesty's Inspectorate for Schools, so that parents couldn't find out which was the best school for their child" and lies about toxic chemical leakages into a popular swimming hole in the Amman river, which caused polio.
However, the vaccine, rather than preventing polio as it was supposed to do, actually caused polio instead.
However, wild polioviruses remain endemic in India, Pakistan, Afghanistan, and Nigeria, occasionally causing polio outbreaks, as in Tajikistan in 2010.
If we were interested in just translational outcomes we would have invested all our money into building better iron lungs instead of investigating the virus that caused polio in the first place.
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