Sentence examples for cause pathway from inspiring English sources

Gain-of-function mutations in JAKs have been observed to cause pathway activation in haematological malignancies.

Whereas BRAF-selective drugs cause pathway activation in a RAS-dependent manner, this does not occur with pan-RAF drugs.

Alternative factors that could cause pathway activation in CNS PNETs include inactivating mutations in the pathway inhibitors AXIN1 and AXIN2.

Without the sugar, the receptor can trigger the cell to grow uncontrollably — a unusual cancer-causing pathway.

Genetic mutations and specific inhibitors are functionally equivalent tools for investigating the order of reactions within metabolic pathways, especially when a highly potent inhibitor causes pathway intermediates to accumulate to levels where they can be chemically or spectroscopically analyzed.

In the latter case, there were three mutated genes causing pathway level difference in 24 pathways.

We suggest an integrated analysis of mutation and gene expression to discover a combination of rare mutations that causes pathway level gene expression changes.

Secondly, based on metabolic control analysis, it can be inferred that this minimization of changes in metabolite concentrations causes pathway fluxes to be minimally sensitive to temperature variations (see Additional file 4).

Targeted cancer therapies block specific molecules involved in cancer-causing pathways.

The PRA integrates all aspects of the problem (causes, pathways, and receptors) without resorting to extensive modeling.

Many researchers believe that a multipronged attack targeted at more than one point in critical cancer-causing pathways could be an effective way to combat resistance.